Antiplatelet Aggregation Activity of 5-Hydroxyflavone, 2’- Hydroxyflavanone, Paeonol and Bergenin Isolated from Stem Bark of Garcinia malaccensis in Human Whole Blood
نویسنده
چکیده
Four known compounds, 5-Hydroxyflavone (1), 2’-Hydroxyflavanone (2), Paeonol (3) and bergenin (4), were isolated from the methanolic extract of the stem bark of Garcinia malaccensis for the first time through combination of vacuum and radial chromatography techniques. The structures of the secondary metabolites (1-4) were elucidated on the basis of their spectroscopic evidence and comparison with the published data. All isolated compounds exhibited inhibition of platelet aggregation in human whole blood which induced by arachidonic acid (AA), adenosine diphosphate (ADP) and collagen. 2’-Hydroxyflavanone (2) showed inhibitory effect on platelet aggregation caused by two inducers with IC 50 47.8± 2.1 AA and 147.2 ± 4.1 ADP.
منابع مشابه
Prenylated Xanthone and Rubraxanthone with Antiplatelet Aggregation Activity in Human Whole Blood Isolated from Garcinia griffithii
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